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Hoshi Lab


Hoshi Scientific Photo

Naoto Hoshi, MD, PhD

Associate Professor of Pharmacology
PhD, 1999, Medical Science, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
MD, 1990, Kanazawa University School of Medicine, Kanazawa, Japan

Dr. Naoto Hoshi's UC Irvine laboratory studies physiological role and regulation of the M-channel, a sub-threshold ion channel that regulates neuronal excitability. We have demonstrated that the AKAP150 macromolecular complex integrates multiple signals to regulate this channel. Genetic removal of AKAP150 resulted in tolerance to seizure induction.

One of our goals is to control pathological neuronal activity through the M-channel modulators. The laboratory is focused on understanding physiological and pathological roles of M-current modulation induced by various neurotransmitters. The laboratory utilizes molecular biology, electrophysiology, live cell FRET imaging and transgenic animals.

Graduate Student Researcher:
    • Derek Green, BS, Pharm/Tox PhD student
Technologies & Research Capabilities
    • Electrophysiology
    • Molecular and cell biology
    • Live cell imaging