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The following shared facilities, equipment and services are available to all department personnel:

Shared Core Facilities »

Shared Core Facilities in Med Surge II:

Analytical facility (Rooms 387, 387A)
Autoclave/dishwasher (Room 389B)
Cold room (Room 366A)
Conference room (Rooms 369A/B)
Microscope room (Room 359A)
Rat behavioral testing rooms (Rooms 358, 358 A-D, 363 A-C)
Surgery room (Room 359)

Pharmacology Shared Equipment »

Shared Equipment located in Med Surge II:

Autoclave (Getinge/Castle 110LS Sterilizer)
Centrifuge, high-speed (Beckman-Coulter J-20XP)
Centrifuge, tabletop (Thermo Forma 5682)
CLAMP system for measuring metabolism
Copier and fax machine (in admin. ofc.)
Cryostat (Microm)
EEG recording and analysis system for sleep
FLIPR (Molecular Devices)
Glassware washer (Getinge/Castle DECOMAT 4656)
Locomotor boxes (5)
Mass spectrometer (Micromass Q-TOF)
Maze (elevated plus)
MCID computer-assisted image analysis system
Microscope (Fluorescence)/Microscope (phase contrast) with computer control
(Carl Zeiss Axiovert/Axioskop)
Q-PCR machine (Applied Biosystems 7700HT)
Scale-microgram (Cahn)
Scintillation counter
Scintillation counter (Beckman)
Self-administration chambers (18 operant)

Shared Equipment located in the Gillespie Neurosciences Research Facility:

High-performance liquid chromatography (1100, Agilent)
Nano-high-performance liquid chromatography (1100, Agilent)
Mass spectrometer (electrospray single quadrupole, Agilent)
Mass spectrometer (electrospray XCT ion trap, Agilent)
Mass spectrometer (CHIP ion trap, Agilent)

Services »

High-Throughput Screening Service
With the completion of the genome sequence, which offers us a variety of new genes to study, and advances in combinatorial chemistry, which delivers large numbers of synthetic compounds to test, high-throughput screening (HTS) is becoming a necessary research endeavor.

We specialize in HTS of G protein-coupled receptors (GPCRs). Ligand recognition is quantified in binding experiments or monitored by second messenger responses. We use FLIPR technology, which allows for real-time fluorescent measurements.

Proteomic Analyses Service
Understanding the broad picture in gene expression requires proteomic analyses. The Q-TOF2 hybrid mass spectrometer and datasystem (MS/MS/DS) is of help in these analyses.

The instrument is equipped with a database searching module for both proteins (BioLynx) and peptides (Proteinlynx) for manual and automatic searching of acquired mass spectometry data against sequence databases (DNA and Protein) in order to identify the unknown samples.

For more information, contact:

Olivier Civelli, PhD
Department of Pharmacology
School of Medicine
University of California, Irvine
Irvine, CA 92697
Tel 949.824.2522
Fax 949.824.4855